Mind + Muscle

technical minds + legal muscle

Sterne Kessler Goldstein Fox
Matthew A. Smith, Ph.D.

Mind + Muscle

Matthew A. Smith, Ph.D.



Dr. Smith is an associate in the Biotechnology/Chemical Group. Dr. Smith’s technical expertise is molecular biology and biochemistry.

He assists in the preparation and prosecution of U.S. and foreign patent applications and has studied the new AIA provisions. He also assists in the preparation of validity, infringement, freedom to operate, and patentability opinions.

While earning his Ph.D., Dr. Smith discovered the degradation mechanism of renal calpain 10. Additionally, Dr. Smith determined that in vitro loss of renal calpain 10 caused mitochondrial dysfunction, increased mitophagy, and increased cell death. While in vivo loss of renal calpain 10 caused increased mitophagy and renal dysfunction. Dr. Smith also has experience in bacteriology as well as the preservation of eukaryotic cells using freeze-drying techniques. Dr. Smith received a National Institutes of Health Environmental Stress Signaling Pre-doctoral training grant.

In law school, Dr. Smith was a Notes Editor for George Mason Law Review and President of George Mason's Intellectual Property Law Society. Additionally, he received the Law Service Award from George Mason School of Law, a Founder's Scholarship from the Federal Circuit Bar Association, and the Sterne, Kessler, Goldstein & Fox scholarship at George Mason School of Law.

Prior to joining the Sterne Kessler, Dr. Smith worked at a boutique intellectual property law firm in McLean, VA where he assisted with patent prosecution.

Legal Publications

Technical Publications

  • Smith, M.A. and Schnellmann, R.G. Calpain 10. Handbook of Proteolytic Enzymes, 3rd Edition, 2013.
  • Smith, M.A., McInnes, C., Whitaker, R.M., Lindsey, C.C., Comer, R.F., Beeson, C.C., and Schnellmann, R.G. Calpain 10 Homology Modeling with CYGAK and Increased Lipophilicity Leads to Greater Potency and Efficacy in Cells. ACS: Chemical Biology, 7(8): 1410-1419, 2012.
  • Smith, M.A. and Schnellmann R.G. Calpains, Mitochondria, and Apoptosis. Cardiovascular Research, 96(1): 32-37, 2012.
  • Smith, M.A., Covington, M.D., and Schnellmann, R.G. Loss of Calpain 10 Causes Mitochondrial Dysfunction During Chronic Hyperglycemia. Archives of Biochemistry and Biophysics, 523(2): 161-168, 2012.
  • Smith, M.A. and Schnellmann, R.G. Mitochondrial Calpain 10 is Degraded by Lon Protease After Oxidant Injury. Archives of Biochemistry and Biophysics, 517(2): 144-152, 2012.

  • Admissions
      • District of Columbia

      • Virginia

      • United States Patent & Trademark Office

  • Education
    • J.D., Patent Law Track, cum laude, George Mason University School of Law

    • Ph.D., Pharmaceutical and Biomedical Sciences, Medical University of South Carolina

    • B.S., Biochemistry, magna cum laude, & B.A., Chemistry, Virginia Polytechnic Institute and State University


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