Sterne Kessler Goldstein Fox

Dr. Nannenga-Combs is an associate in the Biotechnology/Chemical Group.  She assists in the preparation and prosecution of U.S. and foreign patent applications in the areas of biotechnology and cellular and molecular biology.  She also assists in the in the preparation of validity, infringement, freedom to operate and patentability opinions.

Her doctorate research focused on breast cancer, specifically the characterization of PPM1D, a wild-type p53-induced phosphatase, and PPM1D's role in cell cycle and DNA damage response pathways.  Dr. Nannenga-Combs also worked as a technical writer for a Washington-based biopharmaceutical company.

Technical Publications

"Augmented Cancer Resistance and DNA Damage Response Phenotypes in PPM1D Null Mice."  Bonnie Nannenga, Xiongbin Lu, Melissa Dumble, Marc Van Maanen, Thuy-Ai Nguyen, Frances Kittrell, Daniel Medina,T. Rajendra Kumar, and Lawrence A. Donehower.  Molecular Carcinogenesis 2006.

"Dual roles for the phosphatase PPM1D in regulating progesterone receptor function. " Proia DA, Nannenga BW, Donehower LA, Weigel NL.  J Biol Chem. March 2006.

"PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.  " Xiongbin Lu, Bonnie Nannenga, Lawrence A. Donehower.  Genes & Development 2005.

"The p53-Induced Oncogenic Phosphatase Ppm1d Interacts with Uracil DNA Glycosylase and Suppresses Base Excision Repair."  X. Lu, D. Bocangel, B. Nannenga, H. Yamaguchi, E. Appella and L. Donehower.  Molecular Cell 2004.

"Inactivation of the Wip1 Phosphatase Inhibits Mammary Tumorigenesis through p38 MAPK-Mediated Activation on the p16Ink4a-p19Arf Tumor Suppressor Pathway."  D. Bulavin, C. Phillips, B. Nannenga, O. Timofeev, L. Donehower, C. Anderson, E. Appella, A. Fornace Jr.  Nature Genetics 2004.

"Mice Deficient for Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control."  J. Choi, B. Nannenga, O. Demidov, D. Bulavin, A. Cooney, C. Brayton, Y. Zhang, I. Mbawuike, A. Bradley, E. Appella, and L. Donehower.  Molecular and Cellular Biology 2002.

"Enhanced Liver Cell Mutations in Trematode-Infected Big Blue Transgenic Mice. " J. Gentile, G. Gentile, B. Nannenga, M. Johnson, H. Blankespoor, R. Montero.  Mutation Research 1998.