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Sterne Kessler Goldstein Fox
Michael Shane Smith, Ph.D.

Mind + Muscle

Michael Shane Smith, Ph.D.

Technical Specialist

 
  • Michael Shane Smith, Ph.D.
  • p 202.772.8770
  • f 202.371.2540
  • ssmith@skgf.com

  • v-card

Dr. Smith is a technical specialist in the firm's Biotechnology/Chemical Group, where he assists in the preparation and prosecution of patent applications worldwide, collection searches, and freedom-to-operate analyses.  His technical areas of expertise include microbiology, immunology, cell biology, molecular biology, stem cell biology, hematology, and bioinformatics. 

Prior to joining Sterne Kessler, Dr. Smith completed a postdoctoral fellowship at the Oregon Health Sciences University Vaccine and Gene Therapy Institute.  His research was focused on the development of a humanized murine model system to study human cytomegalovirus (HCMV) reactivation during stem cell transplantation.  His studies provided the first HCMV in vivo model system of latency and identified granulocyte-colony stimulating factor (G-CSF) as a clinically relevant trigger of viral reactivation.  Additionally, he developed in vitro macrophage model systems of viral pathogenesis and was involved in testing the efficacy of herpesvirus vector-based vaccines.

Dr. Smith's graduate research focused on the role of peripheral blood mononuclear cells in HCMV dissemination and persistence.  Using leukocytes isolated from human donors, he demonstrated that HCMV exploits circulating monocytes as a Trojan horse to disseminate from the peripheral blood into host tissue, whereby the virus persists.  Dr. Smith's studies revealed that HCMV modulates cellular signal transduction pathways to induce changes in cellular function conducive to viral dissemination and persistence, including resistance to apoptosis, differentiation, and increased transendothelial migration.  Additionally, he was involved in herpes simplex virus and alphavirus cellular attachment and entry studies and in studies on the role of HCMV in angiogenesis.

Dr. Smith is a Louisiana Board of Regents scholar and was the recipient of the LSUHSC Chancellor's Award, the LSUHSC Jason A. Cardelli Award for Cancer Research Excellence, an American Heart Association predoctoral training grant, and an NIH postdoctoral training grant.

Technical Publications:

Coauthor, "Truncation of Herpes Simplex Virus Type 2 Glycoprotein B Increases Its Cell Surface Expression and Activity in Cell-Cell Fusion, but These Properties Are Unrelated." (2002) J. Virol. 76: 9271-83.

Coauthor, "DC-Sign and L-Sign Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses." (2003)  J. Virol. 77: 12022-32.

Smith et al. "HCMV Infection of Monocytes Promotes Macrophage Differentiation and Transendothelial Migration as Potential Mechanisms of Viral Spread." (2004)  J. Virol. 78: 4444-53.

Smith et al. "HCMVActivates PI(3)K in Monocytes and Promotes Monocyte Motility and Transendothelial Migration in a PI(3)K-Dependent Manner." (2004)  J. Leukoc. Biol. 76: 65-66.

Coauthor, "Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naïve Monocyte Extravasation and the Transfer of Productive Virus to Enhance the Hematogenous Dissemination of HCMV." (2006)J. Virol. 80: 11539-11555.

Smith et al. "Roles of Phosphatidylinositol 3-Kinase and NF-kB in Human Cytomegalovirus-Mediated Monocyte Diapedesis and Firm Adhesion: A Strategy for Viral Persistence." (2007) J.Virol. 81: 7683-7694.

Coauthor, "Transcriptome Analysis off NF-kB- and Phosphatidylinositol 3-Kinase-Regulated Genes in Human Cytomegalovirus-Infected Monocytes." (2008) J. Virol. 82: 1040-1046.

Coauthor,"Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation Toward an M1 Macrophage."(2008) J. Immunol. 18: 698-711.

Coauthor, "NF-kB and Phosphatidylinositol 3-kinase activity mediates the HCMV-Induced Atypical M1/M2 Polarization of Monocytes." (2009)  Virus Res. 144: 329-333.

Coauthor, "PI(3)K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes." (2010) J. Immunol. 184: 3213-3222.

Smith et al. "G-CSF Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model." (2010) Cell Host Microbe. 8: 284-291.

Coauthor, "BST2/Tetherin Enhances Entry of Human Cytomegalovirus." (2011) In press, PLoSPathog.

  • Education
    • Ph.D., Microbiology and Immunology, Louisiana State University

    • B.S., Microbiology and Immunology, Louisiana State University summa cum laude

    • B.A., Philosophy, Louisiana State University summa cum laude

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